Melatonin: a promising neuroprotective agent for cerebral ischemia-reperfusion injury
نویسندگان
چکیده
Cerebral ischemia-reperfusion (CIR) injury is initiated by the generation of reactive oxygen species (ROS), which leads to oxidation cellular proteins, DNA, and lipids as an initial event. The reperfusion process impairs critical cascades that support cell survival, including mitochondrial biogenesis antioxidant enzyme activity. Failure activate prosurvival signals may result in increased neuronal death exacerbation CIR damage. Melatonin, a hormone produced naturally body, has high concentrations both cerebrospinal fluid brain. However, melatonin production declines significantly with age, contribute development age-related neurological disorders due reduced levels. By activating various signaling pathways, can affect multiple aspects human health its diverse range activities. Therefore, understanding underlying intracellular molecular mechanisms crucial before investigating neuroprotective effects cerebral injury.
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ژورنال
عنوان ژورنال: Frontiers in Aging Neuroscience
سال: 2023
ISSN: ['1663-4365']
DOI: https://doi.org/10.3389/fnagi.2023.1227513